I use and write software to analyze DNA sequence data. Much has changed in the last couple decades in technology and goals. From Sanger sequencing of SARS, frogs, mice and human genomes or segments of, to 'Next-generation' Illumina sequencing of human cancer. Over the years, I have coordinated teams of up to 10 staff in this field with database development, analysis pipelines, software development, research studies (including two I played a large role in that led to important discoveries), and QA (quality control) of our data and pipelines.
I am currently looking into the use of AI (Artificial Intelligence) for cancer study. This can allow for less invasive and earlier detection of cancer.
Some of my research highlights and projects of interest include:
My first primary author publication in 2002
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117194/
I stayed up to 4am on my own to complete the full genome of the SARS coronovirus in record time in April 2003
http://www.sciencemag.org/content/300/5624/1399.long
See "Cracking the SARS genome" under Media
Linux journal article of the SARS sequencing
http://www.linuxjournal.com/article/6977
Example of how whole genome sequencing used to determine cancer treatment
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945784/
Oligodendroglioma - research project to generate and analyze the first ever genome and RNA sequences of adult oligodendroglioma led to our discovery of a common mutation CIC in this type of brain cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246739/
Publication: Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers*
Semantic Scholar
The Journal of Pathology
* We received the Jeremy Jass Prize for For Research Excellence in Pathology
DIPG - common brain cancer in children
https://www.ncbi.nlm.nih.gov/pubmed/24705252
Medulloblastoma - common malignant brain tumour in children
https://www.ncbi.nlm.nih.gov/pubmed/26760213
A piece of software I wrote, JAGuaR, to help facilitate RNA-sequencing analysis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111418/
http://www.bcgsc.ca/platform/bioinfo/software/jaguar
CV available upon request.
Research Gate
www.researchgate.net/profile/Yaron_Butterfield
I am currently looking into the use of AI (Artificial Intelligence) for cancer study. This can allow for less invasive and earlier detection of cancer.
Some of my research highlights and projects of interest include:
My first primary author publication in 2002
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117194/
I stayed up to 4am on my own to complete the full genome of the SARS coronovirus in record time in April 2003
http://www.sciencemag.org/content/300/5624/1399.long
See "Cracking the SARS genome" under Media
Linux journal article of the SARS sequencing
http://www.linuxjournal.com/article/6977
Example of how whole genome sequencing used to determine cancer treatment
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945784/
Oligodendroglioma - research project to generate and analyze the first ever genome and RNA sequences of adult oligodendroglioma led to our discovery of a common mutation CIC in this type of brain cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246739/
Publication: Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers*
Semantic Scholar
The Journal of Pathology
* We received the Jeremy Jass Prize for For Research Excellence in Pathology
DIPG - common brain cancer in children
https://www.ncbi.nlm.nih.gov/pubmed/24705252
Medulloblastoma - common malignant brain tumour in children
https://www.ncbi.nlm.nih.gov/pubmed/26760213
A piece of software I wrote, JAGuaR, to help facilitate RNA-sequencing analysis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111418/
http://www.bcgsc.ca/platform/bioinfo/software/jaguar
CV available upon request.
Research Gate
www.researchgate.net/profile/Yaron_Butterfield